Dengue NS1 Antigen test report interpretation gives perception into the presence or absence of the dengue virus in a patient’s blood during the early stages of infection. Below is the detailed interpretation:

1. Positive NS1 Antigen Test

• Interpretation:

• • Indicates the presence of the dengue virus in the bloodstream.
  • Confirms detected dengue virus, normally in the early phase (1–7 days after the onset of symptoms).
• Clinical Significance:
  • Medical attention is necessary to track symptoms and avoid problems.
  • Need additional tests like Dengue IgM/IgG or platelet count may be recommended to assess the stage and severity of the infection.
• Action Plan:
  • Start symptomatic treatment (hydration, fever management, etc.).
  • Monitor for warning signs of severe dengue, such as bleeding, abdominal pain, and rapid drop in platelet count.

2. Negative NS1 Antigen Test

• Interpretation:

• • May indicate:

• • • Absence of dengue virus in the bloodstream.
    • A test taken too late in the disease course when the NS1 antigen is no longer detectable.
• Clinical Significance:
  • Does not completely rule out dengue; antibodies (IgM/IgG) may need to be tested.
  • Alternative diagnoses should be explored if dengue symptoms persist.
• Action Plan:
  • Repeat testing with Dengue IgM/IgG or RT-PCR if clinically indicated.
  • Monitor symptoms and investigate other causes of fever.

3. Equivocal or Indeterminate Result

• Interpretation:

• • The result is inconclusive, potentially due to technical issues or borderline levels of the NS1 antigen.
• Action Plan:
  • Retest after 24–48 hours or use additional diagnostic methods (RT-PCR or antibody tests).

Key Notes for Labs:

• Correlate the NS1 antigen test results with clinical symptoms (fever, rash, body aches, etc.) and patient history (travel to dengue-endemic areas).
• Platelet count and hematocrit levels should be evaluated alongside NS1 antigen to assess the risk of severe dengue or complications.